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In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
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In this study, we compared 35 pediatric patients receiving a soy oil lipid emulsion with 35 who received fish oil.
Remarkably, none of the children in the fish oil group experienced blood clots, whereas the soy oil group had ten cases. This suggests that fish oil lipid emulsion may significantly reduce the risk of clots associated with central venous catheters.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
Although DHA showed some benefits, the most significant effects on blood clots came from its oxylipins, specifically 11-HDHA and 14-HDHA. These compounds appeared to inhibit platelet adhesion and thrombus formation through a specific signaling pathway, enhancing the potential for DHA as a treatment for clot-related cardiovascular issues.
Notably, the fish oil reduced the coagulatory activity of these EVs, suggesting a protective effect against thrombus formation. This finding opens up new avenues for preventing blood clots and managing cardiovascular health.
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Frequently Asked Questions
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil is often touted for its cardiovascular benefits, but its relationship with blood clots is nuanced. The omega-3 fatty acids found in fish oil, particularly EPA and DHA, can help reduce inflammation and have been shown to have a mild blood-thinning effect. This may be beneficial for individuals at risk of heart disease, as it can help improve blood circulation and reduce the formation of clots. However, this doesn't mean that fish oil is a substitute for prescribed anticoagulant medications or that it can prevent blood clots entirely.
It's essential to consult a healthcare professional before incorporating omega-3 fish oil into your routine, especially if you're on blood-thinning medications or have existing health conditions. While some studies suggest that higher intakes of omega-3s can support cardiovascular health, the effects can vary based on individual health factors. Always prioritize informed medical advice to tailor supplementation to your unique health profile.
Based on user reviews, the time it takes to see results from taking Omega-3 supplements, particularly for blood clot management, varies among individuals. Many users report noticeable improvements after a month or two of consistent use. For instance, one review highlights a positive change after "two months on this omega," which allowed the user to discontinue their blood pressure medication entirely (Read Review). Another user experienced normal results in their blood tests after "1.5 months" of taking the supplement (Read Review).
In addition, users have noted that they began to feel better and noticed changes, such as reduced blood viscosity or improvements in cholesterol levels, within a few weeks of starting the supplement regime (Read Review) (Read Review). While there are individual variations in response time, these accounts suggest that you may start to see beneficial effects from Omega-3 supplementation between 4 to 8 weeks.
Numerous scientific studies suggest that omega-3 fatty acids, particularly those found in fish oil, may have a positive impact on blood clot prevention and cardiovascular health. For instance, research has demonstrated that fish oil supplementation can significantly reduce the activity of circulating extracellular vesicles associated with clotting, thereby potentially lowering thrombus formation in individuals at moderate risk for cardiovascular diseases [1]. Additionally, a large-scale analysis found that higher intake of omega-3 fatty acids correlated with decreased levels of markers linked to blood coagulation in patients with atrial fibrillation, indicating a protective benefit against blood clots [2].
Further evidence supports the antithrombotic properties of other omega-3 sources, such as Antarctic krill oil, which has been shown to inhibit thrombus formation and enhance protective factors in both animal models and human cells [3]. Moreover, a study involving elderly surgery patients revealed that omega-3 supplementation significantly lowered the incidence of deep vein thrombosis and pulmonary embolism without increasing bleeding complications [6]. Overall, the research indicates a helpful role for omega-3 fatty acids in reducing blood clot risks, making it a noteworthy supplement for those concerned about cardiovascular health and blood clot prevention.
Users have reported a range of notable improvements in their health after using Omega-3 supplements. Many highlight enhancements in skin and hair quality, emphasizing benefits such as healthier skin and improved hair elasticity (Read Review). Additionally, individuals have experienced normalisation in cholesterol levels, with one user reporting significant reductions in triglycerides and "bad" cholesterol after a few months of use (Read Review).
Several users have noted improvements in cardiovascular health, including reduced blood viscosity and improved blood flow (Read Review). Other anecdotal experiences indicate that the supplements can alleviate specific conditions, such as decreased PMS symptoms and better regulation of menstrual cycles (Read Review). Furthermore, some individuals have reported that their blood pressure normalised after starting Omega-3, leading to a noticeable reduction in related symptoms like sudden heartbeats (Read Review). While these anecdotes suggest positive outcomes, it is important to remember that individual results can vary based on personal health conditions and adherence to dosage recommendations.
Users have reported varied experiences when combining Omega-3 supplements, particularly Solgar, with other supplements to manage blood clot and cholesterol levels. One user indicated that they took Omega-3 alongside coenzyme Q10 under their cardiologist's guidance, which significantly helped with their arrhythmia and blood pressure issues (Read Review). Another user highlighted that incorporating Omega-3 into a lifestyle that included dietary improvements and exercise markedly enhanced blood circulation and helped manage elevated triglyceride levels, demonstrating the potential effectiveness of combining supplements with healthy habits (Read Review).
However, caution is advised as some users expressed that high doses of Omega-3 could increase bleeding risk, particularly for those with low blood coagulation (Read Review). Additionally, it’s essential to consult with a healthcare professional before combining Omega-3 with other supplements, especially blood pressure medications, due to possible interactions (Read Review). User experiences suggest that while this combination can yield beneficial effects, medical supervision is crucial to ensure safety and efficacy.
The optimal dose of omega-3 fish oil for reducing blood clot risks appears to be around 1000 mg per day, particularly for specific populations such as elderly patients recovering from surgery. A study that monitored 452 participants showed that this dosage significantly decreased incidents of pulmonary embolism and symptomatic deep vein thrombosis without increasing bleeding complications [6]. Furthermore, other research suggests that higher levels of omega-3s are generally linked to lower blood clot markers in various patient demographics, reinforcing the idea that omega-3 supplementation could help manage clot risk effectively [2].
Notably, the fish oil reduced the coagulatory activity of these EVs, suggesting a protective effect against thrombus formation. This finding opens up new avenues for preventing blood clots and managing cardiovascular health.
This suggests that omega-3s may help reduce blood clot risks. However, while some individual fatty acids showed varied effects, the overall trend points to the potential antithrombotic benefits of these healthy fats.
The results showed that FJH-KO reduced thrombus formation and prolonged bleeding time. It also lowered levels of substances associated with clotting while boosting protective factors. Additionally, in human cells, FJH-KO inhibited the adhesion of immune cells, suggesting its potential as an antithrombotic agent.
References
- Bozbas E, Zhou R, Soyama S, Allen-Redpath K, Mitchell JL, et al. Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived extracellular vesicles: a randomized, controlled crossover trial. Am J Clin Nutr. 2024;119:1175. doi:10.1016/j.ajcnut.2024.03.008
- Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, et al. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation. Nutrients. 2024;16. doi:10.3390/nu16020178
- Lee GH, Lee SY, Chae JY, Kim JW, Kim JH, et al. Antarctic Krill Oil from Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model. Int J Mol Sci. 2023;24. doi:10.3390/ijms242417440
- Pawelzik SC, Arnardottir H, Sarajlic P, Mahdi A, Vigor C, et al. Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19. Free Radic Biol Med. 2023;194:308. doi:10.1016/j.freeradbiomed.2022.12.006
- Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, et al. DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway. J Thromb Haemost. 2021;19:839. doi:10.1111/jth.15184
- Zheng X, Jia R, Li Y, Liu T, Wang Z. Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial. Int Orthop. 2020;44:2089. doi:10.1007/s00264-020-04610-0
- Gaertner S, Auger C, Farooq MA, Pollet B, Khemais-Benkhiat S, et al. Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases. Int J Mol Sci. 2020;21. doi:10.3390/ijms21030920
- Isaksen T, Evensen LH, Brækkan SK, Hansen JB. Dietary Intake of Marine Polyunsaturated n-3 Fatty Acids and Risk of Recurrent Venous Thromboembolism. Thromb Haemost. 2019;119:2053. doi:10.1055/s-0039-1697663
- Carnevale LN, Das A. Novel Anti-inflammatory and Vasodilatory ω-3 Endocannabinoid Epoxide Regioisomers. Adv Exp Med Biol. 2019;1161:219. doi:10.1007/978-3-030-21735-8_17
- Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, et al. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association. Circulation. 2019;140:e673. doi:10.1161/CIR.0000000000000709
- Viecelli AK, Polkinghorne KR, Pascoe EM, Paul-Brent PA, Hawley CM, et al. Fish oil and aspirin effects on arteriovenous fistula function: Secondary outcomes of the randomised omega-3 fatty acids (Fish oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) trial. PLoS One. 2019;14:e0213274. doi:10.1371/journal.pone.0213274
- Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, et al. Fish Oil and Perioperative Bleeding. Circ Cardiovasc Qual Outcomes. 2018;11:e004584. doi:10.1161/CIRCOUTCOMES.118.004584
- Spector AA, Kim HY. Emergence of omega-3 fatty acids in biomedical research. Prostaglandins Leukot Essent Fatty Acids. 2019;140:47. doi:10.1016/j.plefa.2018.11.017
- Tam KW, Wu MY, Siddiqui FJ, Chan ES, Zhu Y, et al. Omega-3 fatty acids for dialysis vascular access outcomes in patients with chronic kidney disease. Cochrane Database Syst Rev. 2018;11:CD011353. doi:10.1002/14651858.CD011353.pub2
- Jami MM, Bhardwaj V, Merritt RJ. Intravenous Fish Oil Lipid Emulsion Prevents Catheter-Related Thromboses in Pediatric Patients with Intestinal Failure. J Pediatr. 2018;198:301. doi:10.1016/j.jpeds.2018.03.029
- Adili R, Voigt EM, Bormann JL, Foss KN, Hurley LJ, et al. In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets. 2019;30:271. doi:10.1080/09537104.2017.1420154
